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Common side effects include appetite loss, erectile dysfunction, nausea and constipation. More severe side effects may include respiratory depression , seizure, addiction, and psychosis. Other side effects may include high heart rate and blood pressure, trouble sleeping, and, rarely, liver toxicity.
As of 2012, use of the cocktail was a severe problem among youth in three provinces along the border of Malaysia and southern Thailand. Kratom may be more potent, but it’s also more likely to cause habituation and dependence. Hirsuta, can cause side effects such as nausea, dependency, or lethargy.
FDA Commissioner Gottlieb stated that the recall was, “…based on the imminent health risk posed by the contamination of this product with salmonella” and not related to other regulatory concerns. Consumers were advised to immediately discard any such products to prevent serious health risks. DEA and a 2020 survey, kratom is used to alleviate pain, anxiety, depression, or opioid withdrawal. Statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.
By technicality, this would mean that other mitragyna plants, as well as extracted alkaloids, are legal. The two most popular and well-studied alkaloids found in kratom are mitragynine and 7-hydroxymitragynine. Neither of these alkaloids is found in Mitragyna hirsuta.
Overdoses of kratom are managed similarly to opioid overdoses, and naloxone can be considered to treat an overdose that results in a reduced impulse to breathe, despite mixed results for its utility, based on animal models. As of 2013, kratom has been studied in cells and in animals, but no clinical trials have been conducted in the United States. The U.S. Drug Enforcement Administration stated in 2013 that there is no legitimate medical use for kratom, and in 2019, the U.S. Food and Drug Administration said that there is no evidence that kratom is safe or effective for treating any condition, and that there are no approved clinical uses for kratom. A product’s sudden popularity doesn’t mean it’s a good investment. It’s another story if that item has been around for centuries and has great medicinal benefits.
From a botanical standpoint, mitragyna hirsuta leaves have a similar structure and appearance to kratom leaves. But it would not be difficult for anyone who is familiar with kratom leaves to tell them apart. I found some Mitragyna hirsuta online and bought it just to compare it to the effects of kratom . I found the effects to be a lot more mild than kratom but present nonetheless. Unlike kratom it didn’t seem to have a great deal of pain reducing properties and did little for my cravings for opioids. However, it had a relaxing effect, improved my mood and made me feel confident.
The amount of alkaloids absorbed into the bloodstream when the plant is chewed allows users to enjoy sustained, consistent energy without becoming overwhelmed by sedation. Mitragyna hirsuta contains many of the same alkaloids as kratom and yet falls outside the legal jurisdiction since it’s a different plant. As such, you can import it legally, even in some places where kratom is considered illegal.
Higher doses are required to enjoy the pain-relieving benefits of Mitragyna hirsuta. Hirsuta causes users to experience stimulation at smaller doses and sedation at higher doses. In February 2018, the commissioner of the FDA, Scott Gottlieb, released a statement describing further opioid-like properties of kratom and stating that it should not be used for any medical treatment or recreational use. Also in 2018, the FDA supervised the voluntary destruction of kratom dietary supplements by a nationwide distributor in Missouri, and encouraged all companies involved in kratom commerce to remove their products from the market.
While there are no places that specifically outlaw Mitragyna hirsuta, some might discourage or outlaw the use of any alkaloids contained in the kratom plant. Mitragyna hirsuta also contains a compound known as Isomitraphylline. This compound shares similar effects as mitraphylline. Isomitraphylline is recognized as the most suitable alkaloid for supplement companies hoping to standardize extracts of cat’s claw. Like kratom, the effects you’ll experience vary depending on how much you take. Lower doses are more likely to produce a stimulating effect, whereas higher doses are more likely to cause sedation or relaxation.
In 2016, we had samples of raw mitragyna hirsuta powder tested, and those results indicated that were no detectable amounts of mitragynine or 7-0H mitragynine in the raw powder. It would be interesting to test different batches of mitragyna hirsuta leaf grown in different regions or harvested at different times. Mitrapylline is another indole alkaloid, and it is also present in cat’s claw vine , Mitraphylline has shown potential to reduce inflammation in studies on mice, and the results did not show any indication of toxicity. Mitragynine also appears to inhibit COX-2, block L-type and T-type calcium channels, and interact with other receptors in the brain including 5-HT2C and 5-HT7 serotonin receptors, D2 dopamine receptors, and A2A adenosine receptors.

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